The Biochemistry of Movement > 9.7.8. Gentle exercise uses type 1 muscles and involves aerobic respiration > The TCA Cycle as Oxidative Decarboxylation >
Outline the TCA cycle as oxidative decarboxylation with the addition of acetyl CoA as the energy source in each cycle
- The removal of a carboxyl group, which releases CO2. The TCA cycle contains many examples of this.
- Oxidation reaction
- Acetyl CoA fuels the TCA cycle.
- Pyruvate is converted into Acetyl CoA via oxidative decarboxylation:
- A carboxyl group is removed from Pyruvate and released as CO2.
- The remaining 2-carbon portion is then oxidised by NAD+. NAD+ gains two hydrogens. The 2-carbon portion becomes acetic acid.
- Coenzyme A attaches itself to the acetic acid, forming acetyl-CoA. This molecule is needed in order for the TCA cycle to continue.